This repository contains the code and material to reproduce the results of the manuscript "International High-sensitivity C-reactive protein reference curves from infancy to young adulthood: findings from the Biomarkers4Pediatrics Collaboration".
The project aims to develop age- and sex-specific reference curves for high-sensitivity C-reactive protein (hs-CRP) in children, adolescents, and young adults using pooled data from Biomarkers4Pediatrics Collaboration.
R/: Main analysis scriptsfunctions/: Helper functionsoutputs/: Figures and tables generated by the analysisdocs/: Notes and documentation
Individual-level data are not stored in this repository. All data files and intermediate datasets are excluded via .gitignore.
- Data preparation and harmonization
- Descriptive analysis
- Percentile curve generation
- Elevated hs-CRP percentages comparison
- Sensitivity analysis of measurement methods
- Leave-one-study-out cross validation (LOSO-CV)