11---
22annotations :
3- - id : PW:0000724
4- parent : drug pathway
5- type : Pathway Ontology
6- value : statin drug pathway
3+ - id : CL:0000182
4+ parent : native cell
5+ type : Cell Type Ontology
6+ value : hepatocyte
77- id : DOID:1287
88 parent : cardiovascular system disease
99 type : Disease Ontology
1010 value : cardiovascular system disease
11+ - id : PW:0000724
12+ parent : drug pathway
13+ type : Pathway Ontology
14+ value : statin drug pathway
1115- id : PW:0001933
1216 parent : disease pathway
1317 type : Pathway Ontology
1418 value : hypercholesterolemia pathway
15- - id : CL:0000182
16- parent : native cell
17- type : Cell Type Ontology
18- value : hepatocyte
1919authors :
2020- Nsalomonis
2121- MaintBot
@@ -46,17 +46,17 @@ description: 'Statins inhibit endogenous cholesterol production by competitive i
4646 of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to
4747 mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates
4848 genes involved in statin pharmacogenomics, including genes involved in mediating
49- the effects of statins on plasma lipoprotein metabolism. Sources: [https://www.pharmgkb.org/pathway/PA2031
50- PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia] '
51- last-edited : 2024-07-06
49+ the effects of statins on plasma lipoprotein metabolism. Sources: [PharmGKB]( https://www.pharmgkb.org/pathway/PA2031)
50+ and [Wikipedia]( http://en.wikipedia.org/wiki/Statin) '
51+ last-edited : 2025-03-03
5252ndex : null
5353organisms :
5454- Mus musculus
5555redirect_from :
5656- /index.php/Pathway:WP1
5757- /instance/WP1
58- - /instance/WP1_r134146
59- revision : r134146
58+ - /instance/WP1_r137182
59+ revision : r137182
6060schema-jsonld :
6161- ' @context ' : https://schema.org/
6262 ' @id ' : https://wikipathways.github.io/pathways/WP1.html
@@ -69,8 +69,7 @@ schema-jsonld:
6969 to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway
7070 delineates genes involved in statin pharmacogenomics, including genes involved
7171 in mediating the effects of statins on plasma lipoprotein metabolism. Sources:
72- [https://www.pharmgkb.org/pathway/PA2031 PharmGKB] and [http://en.wikipedia.org/wiki/Statin
73- Wikipedia]'
72+ [PharmGKB](https://www.pharmgkb.org/pathway/PA2031) and [Wikipedia](http://en.wikipedia.org/wiki/Statin)'
7473 keywords :
7574 - Abca1
7675 - Acetyl-CoA
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