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_pathways/WP1.md

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---
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annotations:
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- id: PW:0000724
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parent: drug pathway
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type: Pathway Ontology
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value: statin drug pathway
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- id: CL:0000182
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parent: native cell
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type: Cell Type Ontology
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value: hepatocyte
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- id: DOID:1287
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parent: cardiovascular system disease
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type: Disease Ontology
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value: cardiovascular system disease
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- id: PW:0000724
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parent: drug pathway
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type: Pathway Ontology
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value: statin drug pathway
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- id: PW:0001933
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parent: disease pathway
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type: Pathway Ontology
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value: hypercholesterolemia pathway
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- id: CL:0000182
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parent: native cell
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type: Cell Type Ontology
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value: hepatocyte
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authors:
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- Nsalomonis
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- MaintBot
@@ -46,17 +46,17 @@ description: 'Statins inhibit endogenous cholesterol production by competitive i
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of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to
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mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates
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genes involved in statin pharmacogenomics, including genes involved in mediating
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the effects of statins on plasma lipoprotein metabolism. Sources: [https://www.pharmgkb.org/pathway/PA2031
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PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia]'
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last-edited: 2024-07-06
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the effects of statins on plasma lipoprotein metabolism. Sources: [PharmGKB](https://www.pharmgkb.org/pathway/PA2031)
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and [Wikipedia](http://en.wikipedia.org/wiki/Statin)'
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last-edited: 2025-03-03
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ndex: null
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organisms:
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- Mus musculus
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redirect_from:
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- /index.php/Pathway:WP1
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- /instance/WP1
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- /instance/WP1_r134146
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revision: r134146
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- /instance/WP1_r137182
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revision: r137182
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schema-jsonld:
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- '@context': https://schema.org/
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'@id': https://wikipathways.github.io/pathways/WP1.html
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to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway
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delineates genes involved in statin pharmacogenomics, including genes involved
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in mediating the effects of statins on plasma lipoprotein metabolism. Sources:
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[https://www.pharmgkb.org/pathway/PA2031 PharmGKB] and [http://en.wikipedia.org/wiki/Statin
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Wikipedia]'
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[PharmGKB](https://www.pharmgkb.org/pathway/PA2031) and [Wikipedia](http://en.wikipedia.org/wiki/Statin)'
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keywords:
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- Abca1
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- Acetyl-CoA

assets/img/WP1/WP1-thumb.png

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