SponsorBlock is fully usable with the videos downloaded by this script thanks to MPV_SponsorBlock by po5 / Eva since this issue.
To use it you just have to set: local_pattern = " %[([%a%d%-_]+)].[mw][kpe][v4b]m?$" in sponsorblock.lua.
Note that this will send/leak to the SponsorBlock server everything that use this naming including "CRCs in anime-style naming".