Actually I'm trying to explore the Programmig -> PID Controllers.
I have setup a simple PID Controller: enabled, setpoint=0, measurement=roll, P=1000 (=1.0), I=D=FF=0.
If I "save" these values, the PID-Controller looks inactive, it produces output constantly 0. Powercycling the FC seems to help. The same is true for changing the coefficients of the PID controller: "saving" the new values do not make them active, it is required to reboot the FC.
This looks like a bug, because the logs say that the values are saved. But the new values do not have any effect.
P.S. "Saving" new ranges of channel values in the "Modes" tab makes them used without a reboot. This seems to be the correct behaviour.