diff --git a/app/frontend/entrypoints/ui_v2.scss b/app/frontend/entrypoints/ui_v2.scss
index 03986c0a6..c356be19d 100644
--- a/app/frontend/entrypoints/ui_v2.scss
+++ b/app/frontend/entrypoints/ui_v2.scss
@@ -5,3 +5,11 @@
 .letter-spacing-wide {
   letter-spacing: 0.4px;
 }
+
+.border-start-md {
+  border-left: none !important;
+
+  @media (min-width: 768px) {
+    border-left: var(--bs-border-width) var(--bs-border-style) var(--bs-border-color) !important;
+  }
+}
diff --git a/app/frontend/src/app/routes/settings/index.tsx b/app/frontend/src/app/routes/settings/index.tsx
index 8dbc71313..3acb16aa5 100644
--- a/app/frontend/src/app/routes/settings/index.tsx
+++ b/app/frontend/src/app/routes/settings/index.tsx
@@ -15,7 +15,7 @@ const SettingsIndexRoute = () => {
         <Col md={7}>
           <UserForm user={user.data} isEditingSelf={true} />
         </Col>
-        <Col md={{ span: 4, offset: 1 }} style={{ borderLeft: '1px solid #ddd', paddingLeft: '20px' }}>
+        <Col md={{ span: 4, offset: 1 }} className="border-start-md pt-4 pt-md-0 ps-md-4">
           <UserAPIKeyGenerationForm userUid={user.data.uid} apiKeyDigest={user.data.apiKeyDigest} />
         </Col>
       </Row>
diff --git a/app/frontend/src/app/routes/users/__tests__/project-permissions.test.tsx b/app/frontend/src/app/routes/users/__tests__/project-permissions.test.tsx
index c04b065e2..a4089af8f 100644
--- a/app/frontend/src/app/routes/users/__tests__/project-permissions.test.tsx
+++ b/app/frontend/src/app/routes/users/__tests__/project-permissions.test.tsx
@@ -225,7 +225,7 @@ describe('User Project Permissions Route', () => {
       });
     });
 
-    describe('removing permissions', () => {
+    describe('removing individual permissions', () => {
       it('should remove a project row when clicking Delete', async () => {
         const permissions = [
           buildProjectPermission({ projectId: 1, projectDisplayLabel: 'Project To Keep', projectStringKey: 'keep' }),
@@ -249,5 +249,82 @@ describe('User Project Permissions Route', () => {
         expect(screen.getByText(/you have unsaved changes/i)).toBeInTheDocument();
       });
     });
+
+    describe('clearing all permissions', () => {
+      it('should disable the Remove All button when user has no permissions', async () => {
+        mockNonAdminPermissionsAPIs('regular-user');
+
+        await renderApp(<UserProjectsRoute />, {
+          path: '/users/:userUid/project-permissions/edit',
+          url: '/users/regular-user/project-permissions/edit',
+        });
+
+        await screen.findByRole('button', { name: /save changes/i });
+
+        expect(
+          screen.getByRole('button', { name: /remove all project permissions/i }),
+        ).toBeDisabled();
+      });
+
+      it('should enable the Remove All button when user has permissions', async () => {
+        const permissions = [buildProjectPermission()];
+
+        mockNonAdminPermissionsAPIs('regular-user', { permissions });
+
+        await renderApp(<UserProjectsRoute />, {
+          path: '/users/:userUid/project-permissions/edit',
+          url: '/users/regular-user/project-permissions/edit',
+        });
+
+        await screen.findByText('Test Project Alpha');
+
+        expect(
+          screen.getByRole('button', { name: /remove all project permissions/i }),
+        ).toBeEnabled();
+      });
+
+      it('should remove all project rows when clicking Remove All', async () => {
+        const permissions = [
+          buildProjectPermission({ projectId: 1, projectDisplayLabel: 'Project One', projectStringKey: 'one' }),
+          buildProjectPermission({ projectId: 2, projectDisplayLabel: 'Project Two', projectStringKey: 'two' }),
+        ];
+
+        mockNonAdminPermissionsAPIs('regular-user', { permissions });
+
+        await renderApp(<UserProjectsRoute />, {
+          path: '/users/:userUid/project-permissions/edit',
+          url: '/users/regular-user/project-permissions/edit',
+        });
+
+        await screen.findByText('Project One');
+        expect(screen.getByText('Project Two')).toBeInTheDocument();
+
+        await userEvent.click(
+          screen.getByRole('button', { name: /remove all project permissions/i }),
+        );
+
+        expect(screen.queryByText('Project One')).not.toBeInTheDocument();
+        expect(screen.queryByText('Project Two')).not.toBeInTheDocument();
+        expect(screen.getByText(/no project permissions assigned/i)).toBeInTheDocument();
+      });
+
+      it('should disable the Remove All button after clearing all permissions', async () => {
+        const permissions = [buildProjectPermission()];
+
+        mockNonAdminPermissionsAPIs('regular-user', { permissions });
+
+        await renderApp(<UserProjectsRoute />, {
+          path: '/users/:userUid/project-permissions/edit',
+          url: '/users/regular-user/project-permissions/edit',
+        });
+
+        await screen.findByText('Test Project Alpha');
+
+        const clearAllButton = screen.getByRole('button', { name: /remove all project permissions/i });
+        await userEvent.click(clearAllButton);
+
+        expect(clearAllButton).toBeDisabled();
+      });
+    });
   });
 });
\ No newline at end of file
diff --git a/app/frontend/src/components/ui/table-builder/table-header.tsx b/app/frontend/src/components/ui/table-builder/table-header.tsx
index a1620dfed..e2212ceb6 100644
--- a/app/frontend/src/components/ui/table-builder/table-header.tsx
+++ b/app/frontend/src/components/ui/table-builder/table-header.tsx
@@ -7,19 +7,21 @@ interface TableHeaderProps<T> {
 
 function TableHeader<T>({ headerGroup }: TableHeaderProps<T>) {
   const renderSortingIcon = (sortDirection: 'asc' | 'desc' | null) => {
+    const sharedClassNames = 'ms-2 flex-shrink-0 mt-1'
+
     if (sortDirection === 'asc') {
-      return <ArrowUp className="ms-2" size={14} />
+      return <ArrowUp className={sharedClassNames} size={14} />
     }
     if (sortDirection === 'desc') {
-      return <ArrowDown className="ms-2" size={14} />
+      return <ArrowDown className={sharedClassNames} size={14} />
     }
-    return <ArrowDownUp className="ms-2" style={{ color: '#b5b5b5ff' }} size={14} />
+    return <ArrowDownUp className={sharedClassNames} style={{ color: '#b5b5b5ff' }} size={14} />
   }
 
   const createColumnHeader = (header: HeaderGroup<T>) => {
     if (header.isPlaceholder) return null
 
-    const sharedClassNames = 'fw-semibold d-flex justify-content-between m-0 p-0 align-items-center'
+    const sharedClassNames = 'fw-semibold d-inline-flex m-0 p-0 align-items-start text-start'
     const headerText = flexRender(header.column.columnDef.header, header.getContext())
 
     if (header.column.getCanSort()) {
diff --git a/app/frontend/src/features/users/components/copy-other-user-permissions-display.tsx b/app/frontend/src/features/users/components/copy-other-user-permissions-display.tsx
index cd856faa1..ad1d14b24 100644
--- a/app/frontend/src/features/users/components/copy-other-user-permissions-display.tsx
+++ b/app/frontend/src/features/users/components/copy-other-user-permissions-display.tsx
@@ -1,4 +1,3 @@
-import React from 'react';
 import { Button, Row, Col } from 'react-bootstrap';
 import { User } from '@/types/api';
 import { AutocompleteSelect } from '@/components/ui/autocomplete-select';
@@ -19,9 +18,7 @@ export const CopyOtherPermissionsDisplay = ({
 }: CopyOtherPermissionsDisplayProps) => {
   return (
     <div className="mb-4" style={{ borderBottom: '1px solid #dee2e6', paddingBottom: '1.5rem' }}>
-      <p>You can copy another user&apos;s project permissions by selecting their name from a dropdown. The permissions will be merged with any existing permissions.
-        <br />
-        Don&apos;t worry, you can still make individual adjustments before saving.
+      <p>You can copy project permissions from another user to this one by selecting the other user&apos;s name from the dropdown list below.
       </p>
       <Row className="g-2 align-items-center">
         <Col md={4}>
diff --git a/app/frontend/src/features/users/components/user-edit.tsx b/app/frontend/src/features/users/components/user-edit.tsx
index 2113e74ef..f7ee38dfe 100644
--- a/app/frontend/src/features/users/components/user-edit.tsx
+++ b/app/frontend/src/features/users/components/user-edit.tsx
@@ -22,7 +22,7 @@ export const UserEdit = ({ userUid }: { userUid: string }) => {
         <Col md={7}>
           <UserForm user={user} />
         </Col>
-        <Col md={{ span: 4, offset: 1 }} className="border-start ps-4">
+        <Col md={{ span: 4, offset: 1 }} className="border-start-md pt-4 pt-md-0 ps-md-4">
           <UserAPIKeyGenerationForm userUid={user.uid} apiKeyDigest={user.apiKeyDigest} />
         </Col>
       </Row>
diff --git a/app/frontend/src/features/users/components/user-project-permissions-form.tsx b/app/frontend/src/features/users/components/user-project-permissions-form.tsx
index 6d12e3228..9bac4da2d 100644
--- a/app/frontend/src/features/users/components/user-project-permissions-form.tsx
+++ b/app/frontend/src/features/users/components/user-project-permissions-form.tsx
@@ -23,6 +23,7 @@ export const UserProjectPermissionsForm = ({ userUid }: { userUid: string }) =>
     addPermission,
     updatePermission,
     removePermission,
+    removeAllPermissions,
     hasChanges,
     handleSave,
     isError,
@@ -86,6 +87,16 @@ export const UserProjectPermissionsForm = ({ userUid }: { userUid: string }) =>
         mergeUserPermissions={mergePermissions}
       />
 
+      <div className="d-flex justify-content-end pt-2">
+        <Button
+          variant="btn btn-sm btn-outline-secondary"
+          onClick={removeAllPermissions}
+          disabled={data.length === 0 || mutation.isPending}
+        >
+          Remove All Project Permissions
+        </Button>
+      </div>
+
       <ProjectPermissionsTable
         data={data}
         unassignedProjects={unassignedProjects}
diff --git a/app/frontend/src/features/users/hooks/use-project-permissions-form.tsx b/app/frontend/src/features/users/hooks/use-project-permissions-form.tsx
index 6d2c4b774..9076ab71d 100644
--- a/app/frontend/src/features/users/hooks/use-project-permissions-form.tsx
+++ b/app/frontend/src/features/users/hooks/use-project-permissions-form.tsx
@@ -52,6 +52,10 @@ export const useProjectPermissionsForm = ({ userUid }: UseProjectPermissionsForm
     setData((old) => old.filter((_, index) => index !== rowIndex));
   }, []);
 
+  const removeAllPermissions = useCallback(() => {
+    setData([]);
+  }, []);
+
   const mergePermissions = useCallback(() => {
     if (!selectedUserUid || !selectedUserPermissionsQuery.data) return;
 
@@ -98,6 +102,7 @@ export const useProjectPermissionsForm = ({ userUid }: UseProjectPermissionsForm
     addPermission,
     updatePermission,
     removePermission,
+    removeAllPermissions,
     handleSave,
     mutation: updatePermissionsMutation,
     // Copy permissions from another user